Stem cell factor enhances in vivo effects of granulocyte colony stimulating factor for stimulating mobilization of peripheral blood progenitor cells

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Abstract
Granulocyte colony stimulating factor (G‐CSF) has been shown to increase peripheral blood progenitor cells (PBPC) which have an enhanced engraftment potential in autologous transplantation compared with bone marrow cells. The data presented in this study demonstrate the ability of low doses of stem cell factor (SCF) to synergize with G‐CSF to enhance the mobilization of PBPC, compared with G‐CSF alone, in both mouse and primate models. In the mouse model the combination of SCF plus G‐CSF stimulated an absolute increase in cells with in vivo repopulating potential. These studies suggest a possible role for SCF plus G‐CSF in the clinical setting for increased mobilization of PBPC, giving rise to increased phoresis yields and enhanced engraftment for support of high‐dose chemotherapy.

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