A 'unified theory' of prion propagation
- 1 August 1991
- journal article
- review article
- Published by Springer Nature in Nature
- Vol. 352 (6337) , 679-683
- https://doi.org/10.1038/352679a0
Abstract
There is now very persuasive evidence that the transmissible agent for spongiform encephalopathies such as scrapie, consists of a modified form of the normal host protein PrPc, devoid of any nucleic acid. On the other hand, because there are many different strains of scrapie agent with distinct phenotypes which can be propagated in animals homozygous for the PrPc gene, it has been suggested that a nucleic acid must be a component of the agent. Can the two views be reconciled?Keywords
This publication has 96 references indexed in Scilit:
- Variation in the characteristics of 10 mouse-passaged scrapie lines derived from five scrapie-positive sheepJournal of General Virology, 1991
- The prion's progressNature, 1991
- Nuclease treatment results in high specific purification of Creutzfeldt-Jakob disease infectivity with a density characteristic of nucleic acid-protein complexesArchiv für die gesamte Virusforschung, 1990
- Scrapie prion proteins accumulate in the cytoplasm of persistently infected cultured cells.The Journal of cell biology, 1990
- Genetic engineering of plants for virus resistanceArchiv für die gesamte Virusforschung, 1990
- Mutations in familial Creutzfeldt-Jakob disease and Gerstmann-Sträussler-Scheinker's syndromeExperimental Neurology, 1989
- Pro→Leu change at position 102 of prinon protein is the most common but not the sole mutation related to Gerstmann-Sträussler syndromeBiochemical and Biophysical Research Communications, 1989
- Sheep disease in human clothingNature, 1989
- Temporary and Permanent Modifications to a Single Strain of Mouse Scrapie on Transmission to Rats and HamstersJournal of General Virology, 1987
- Identification of scrapie prion protein-specific mRNA in scrapie-infected and uninfected brainNature, 1985