Cardiac Arrhythmia Induced by Negative Phase in Artificial Ventilation

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Abstract
Ventricular bigeminy appeared consistently when a negative phase was introduced into the cycling pattern, and disappeared when positive phasing only was applied. The subatmospheric tracheal pressure apparently triggered the ventricular arrhythmia. This was probably evident only because the heart was rendered irritable by hypothermia. The actual mechanism is unclear. The subatmospheric pressure in the trachea may initiate a vagal reflex such as is common during manipulation of the tracheobronchial tree during pulmonary surgery.

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