Synthesis of (1R,4R)- and (1S,4S)-2,5-Diazabicyclo[2.2.1]heptanes and TheirN-Substituted Derivatives

1 January 1990

journal article
research article
Published by Georg Thieme Verlag KG in Synthesis

Vol. 1990 (10) , 925-930
https://doi.org/10.1055/s-1990-27056

Abstract

Derivatives of the (1R,4R)- and (1S,4S)-2,5-diazabicyclo- [2.2.1]heptane ring system are prepared in enantiomerically pure form from trans-4-hydroxy-L-proline (2). The target compounds are precursors of antibacterial quinolone carboxyclic acids.

Keywords

HEPTANES
DIAZABICYCLO
SUBSTITUTED DERIVATIVES
HEPTANE RING
PURE FORM
QUINOLONE CARBOXYCLIC
ENANTIOMERICALLY PURE
RING SYSTEM
TARGET COMPOUNDS
ANTIBACTERIAL QUINOLONE