Human Recombinant Lymphokines and Cytokines Induce Pulmonary Eosinophilia in the Guinea Pig which Is Inhibited by Ketotifen and AH 21–132
- 1 January 1990
- journal article
- research article
- Published by S. Karger AG in International Archives of Allergy and Immunology
- Vol. 91 (4) , 354-361
- https://doi.org/10.1159/000235141
Abstract
Subcutaneous or intraperitoneal injection of recombinant human granulocyte-macrophage colony-stimulating factor, interleukin 3, or mouse tumour necrosis factor alpha, but not recombinant human interferon gamma, platelet-derived growth factor, or transforming growth factor beta caused selective eosinophilia of the pulmonary airways in the guinea pig. Unlike responses to latelet-activating factor, there was no attendant detectable airway hyperreactivity, but in common with responses to platelet-activating factor, eosinophilia of the airways was prevented by pretreatment with ketotifen or AH 21–132. Cytokines or lymphokines may contribute to pulmonary eosinophilia in diseases such as asthma.Keywords
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