A Humoral Suppressor of in Vitro Lymphocyte Transformation Responses in Cattle with Johne's Disease

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Abstract
Summary Cattle with Johne's Disease, a chronic mycobacterial infection, often have a cutaneous anergy. The lymphocytes from a Johne's Disease affected animal responded poorly to phytohemagglutinin (PHA) when incubated in autologous plasma. When the cells were washed and incubated in normal plasma, the PHA responses returned to normal values. Sera from these cattle also were found to inhibit PHA-induced transformation of normal peripheral blood lymphocytes. When the immunosuppressive serum from one of these animals was fractionated by ion-exchange chromatography the suppressor of lymphocyte transformation was recovered in the fractions containing immunoglobulins G1 and G2.

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