Digitalis

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Abstract
Digitalis ToxicityEpidemiologyWithering's account of the therapeutic efficacy of foxglove was accompanied by a perceptive discussion of toxic manifestations, including a case report of fatal overdosage.283 Toxic manifestations of digitalis persist as one of the most prevalent adverse drug reactions encountered in clinical practice.284 , 285 The incidence in hospitalized patients is reported to vary between 8 and 35 per cent,213,214,249, 284 285 286 287 288 289 290 291 with mortality attributable to cardiac toxicity ranging from 3 to 21 per cent of those intoxicated.289 , 290 , 292 , 293 The variability of these data relate to differing definitions of digitalis intoxication, the retrospective nature of many of these studies, and differences in the . . .

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