The Effect of Strain and Diet on the Thirty-Day Mortality of X-Irradiated Germfree Mice

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Abstract
Germ-free and conventionally reared mice of the inbred RFM and noninbred ICR and CF No. 1 strains were exposed at -100 r/min to 500 to 1000 r of whole-body X-rays (half-value layer 1.0 mm Cu). In each strain, germfree mice had a higher LD50(30) than their conventional counterparts, but the difference in LD50(30) between germfree and conventional mice varied with strain from 147 r for RFM males to 34 r for CF No. 1 mice. The LD50(30) of different strains varied only one-half as much in germfree mice as in conventional mice, and the order of strain radiosensitivity was different for conventional and germfree mice. Supplementation of the autoclaved diet with a filter-sterilized synthetic diet increased the LD50(30) of germfree ICR mice from 790 to 900 r, changed the slope of the mortality curve and the mean survival time, and decreased weight loss after irradiation.

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