From Phosphonates to Catalytic Antibodies. A Novel Route to Phosphonoester Transition State Analogs and Haptens
- 1 March 1993
- journal article
- research article
- Published by Taylor & Francis in Phosphorus, Sulfur, and Silicon and the Related Elements
- Vol. 76 (1-4) , 123-126
- https://doi.org/10.1080/10426509308032374
Abstract
We present here a newly developed approach based on DBU catalyzed transesterification of bis-PNP-phosphonates, used for the preparation of phosphonoesters and their protein conjugates. These are being used, as transition state analogs, to elicit catalytic antibodies having enzyme-like properties.Keywords
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