Cefamandole: In Vitro and Clinical Pharmacokinetics

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Abstract
Cefamandole has a broader spectrum and greater potency than the other cephalosporins. It includes Haemophilus influenzae , most strains of Enterobacter , and many strains of indole-positive Proteus and Bacteroides , with a lower minimal inhibitory concentration for Escherichia coli, Klebsiella , etc. Concentrations of drug in the serum after the parenteral injection of cefamandole exceed manyfold the minimal inhibitory concentrations of over 82% of the bacteria studied. Approximately 65 to 85% is excreted in a biologically active form in the urine. This antibiotic offers advantages of antibacterial effectiveness and at the same time retains the safety of penicillin G and cephalothin in animals.