A 1H and 13C nuclear magnetic resonance study of three quaternary salts of naloxone and oxymorphone

Abstract
The information from 1H–1H and 1H–13C correlation n.m.r. spectra allowed a complete assignment of the 1H and 13C spectra of three N,N-dialkylmorphinanium chloride derivatives (one N,N-diallyl and two N-allyl-N-methyl diastereoisomers). In the case of the steroisomers the configuration of the asymmetric N atom could be established on the basis of 1H chemical shift data and nuclear Overhauser effects.

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