Abnormal Lymphocyte Profiles and Leukotriene B4 Status in a Patient with Crohn's Disease and Severe Periodontitis

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Abstract
This case report describes clinical and laboratory findings for a 60‐year‐old woman with recently diagnosed Crohn's disease and severe generalized Periodontitis. Comparison of dental radiographs taken in 1975, in 1983, and at the time of our evaluation in 1986 revealed dramatic progression of alveolar bone loss over that period. Standard laboratory blood tests did not reveal any remarkable significant leukocyte abnormalities, but flow cytometric analysis of lymphocytes revealed a paucity of B cells stained with anti‐light chain antibodies, and an increased proportion of T lymphocytes which were dully‐stained with anti‐CD5 monoclonal antibody. B cell function as determined by in vitro proliferative responsiveness to anti‐IgM antibody was only about 50% of that observed with cells from two healthy normal subjects. Serum leukotriene B4 (LTB4) was elevated to 150% of normal values, in spite of the fact that the patient was taking a systemic anti‐inflammatory drug which is known to reduce LTB4 levels. The microbial flora was highly mixed and included several putative periodontopathic bacteria. Therapy consisted of oral hygiene instruction, scaling and root planing, mucoperiosteal‐flap curettage, extracoronal splinting, and selective extraction of three teeth. The periodontal status improved markedly with therapy. Possible relationships between the patient's immunological status, her Crohn's disease, and the severe periodontal breakdown are discussed.
Funding Information
  • National Institutes of Health (DE02600)