Protection studies against Marek's disease using baculovirus‐expressed glycoproteins B and C of Marek's disease virus type 1
Open Access
- 1 March 1996
- journal article
- research article
- Published by Taylor & Francis in Avian Pathology
- Vol. 25 (1) , 5-24
- https://doi.org/10.1080/03079459608419116
Abstract
Glycoproteins B (MDV1‐gB) and C (MDV1‐gC) of Marek's disease virus type 1 (MDV 1) expressed by baculovirus recombinants [rAcNPV(s)] were investigated for their ability to confer protective immunity in chickens against virulent MDV1 challenge. Immunization of chickens with rAcNPV‐expressed MDV1‐gB induced antibody against MDV1 and resulted in strong protection against the lethal challenge with MDV1. In contrast, immunization of chickens with rAcNPV‐expressed MDV1‐gC induced antibody against MDV1, but failed to protect against challenge with the virulent MDV1. Co‐immunization with both rAcNPV‐expressed MDV1‐gB and MDV1‐gC seemed to show no synergistic effect.Keywords
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