The effect of atrial natriuretic factor on urinary albumin and ??; 2-microglobulin excretion in man
- 1 October 1988
- journal article
- research article
- Published by Wolters Kluwer Health in Journal Of Hypertension
- Vol. 6 (10) , 783???786
- https://doi.org/10.1097/00004872-198810000-00003
Abstract
The effect of a 20-min infusion of atrial natriuretic factor (ANF) 99–126, 0.4 jxg/kg per min, on both urinary albumin and β;2-microglobulin excretion was examined in nine normal male subjects during stable water diuresis. ANF caused a rise in urinary albumin in excretion (from 4.19 ±; 0.66 to 13.49 ±;3.07 ng/min, P < 0.01) without any significant change in either creatinine clearance of β;2-microglobulin excretion. These findings suggest that ANF may enhance glomerular permeability to albumin in man.Keywords
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