COMPENSATORY ADRENAL HYPERTROPHY AS A POSSIBLE CAUSE OF METACORTICOID HYPERTENSION1
- 1 March 1960
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 66 (3) , 428-432
- https://doi.org/10.1210/endo-66-3-428
Abstract
Desoxycorticosterone acetate (DCA), cortisone or cortisol elicited hypertension which, after discontinuation of treatment, persisted only in the DCA-treated group. This self-sustained hypertension is not dependent upon adrenal hypertrophy subsequent to compensatory adrenal atrophy, nor on the presence of renal lesions. DCA and cortisol, but not cortisone, caused nephrosclerosis; similar lesions accompanied by massive myocardial hemorrhages and necroses were obtained with ACTH but only after cortisone pretreatment.Keywords
This publication has 1 reference indexed in Scilit:
- THE BIOLOGY OF METACORTICOID HYPERTENSIONAnnals of Internal Medicine, 1958