Disruption of Tight Junctions by Cellulose Sulfate Facilitates HIV Infection: Model of Microbicide Safety
Open Access
- 15 August 2009
- journal article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 200 (4) , 599-608
- https://doi.org/10.1086/600867
Abstract
BackgroundThe lack of biomarkers that are predictive of safety is a critical gap in the development of microbicides. The present experiments were desKeywords
This publication has 35 references indexed in Scilit:
- SAVVY Vaginal Gel (C31G) for Prevention of HIV Infection: A Randomized Controlled Trial in NigeriaPLOS ONE, 2008
- Seminal Plasma Reduces the Effectiveness of Topical Polyanionic MicrobicidesThe Journal of Infectious Diseases, 2007
- Safety and acceptability of 6% cellulose sulfate vaginal gel applied four times per day for 14 daysContraception, 2007
- The role of junctional adhesion molecules in vascular inflammationNature Reviews Immunology, 2007
- A Comprehensive Murine Model to Evaluate Topical Vaginal Microbicides: Mucosal Inflammation and Susceptibility to Genital Herpes as Surrogate Markers of SafetyThe Journal of Infectious Diseases, 2007
- Hyperosmolar Sexual Lubricant Causes Epithelial Damage in the Distal Colon: Potential Implication for HIV TransmissionThe Journal of Infectious Diseases, 2007
- Cell-Free Human Immunodeficiency Virus Type 1 Transcytosis through Primary Genital Epithelial CellsJournal of Virology, 2007
- Nested Case–Control Study of Cervical Mucosal Lesions, Ectopy, and Incident HIV Infection Among Women in Cape Town, South AfricaSexually Transmitted Diseases, 2006
- Fourteen-day safety and acceptability study of 6% cellulose sulfate gel: a randomized double-blind Phase I safety studyContraception, 2006
- Safety and acceptability of cellulose sulfate as a vaginal microbicide in HIV-infected womenAIDS, 2006