Hexestrol: Clinical Study of a New Synthetic Estrogen

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Abstract
In cases of menopause, hexestrol was more effective than diethylstilbestrol because there was less nausea and no uterine bleeding as with diethylstilbestrol. Doses of 3 mg. 1 to 3 times a day, were effective for the treatment of dysfunctional uterine bleeding and menorrhagia. The 3-mg. tablets were given at 9 P.M. for 3 nights, then one 3-mg. tablet 3 times a day for 3 days. The 3-mg. dose was gradually increased every day until tolerance was reached, which was usually 3-6 mg., 3 times a day. The medication could be taken only at night if the patient wished. If the bleeding was severe, 75-100 mg. of hexestrol was injected at once into the anterior wall of the cervix or intramusc, followed by 6-9 mg. orally every 15 min. until bleeding stopped, then 6-9 mg. 3 times a day for 3-4 mos. along with 1-5 grains of thyroid/day for 6-12 mos. In the case of nausea, 11/2 grains of nembutal or phenobar-bital was given. In menopause cases, the patient was given 0.5 mg. of hexestrol orally 3 times a day for 2 days, then the dosage was increased by 0.5 mg. every 2 days until the patient detd. the amt. required to relieve the menopausal symptoms. Since uterine bleeding was not produced with hexestrol, it should be used instead of diethylstilbestrol for the treatment of menopause symptoms. Laboratory tests before, during and after the adm. of hexestrol were normal, so it is apparent that the drug is not very toxic even in large unphysiological and exptl. doses.

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