Stimulation of Gastric Secretion by Urticariogenic Wetting Agent (Tween 20) and Its Inhibition by Benadryl

1 July 1948

journal article
research article
Published by Frontiers Media SA in Experimental Biology and Medicine

Vol. 68 (3) , 550-552
https://doi.org/10.3181/00379727-68-16549

Abstract

Tween 20 produces urticaria and stimulates gastric secretion when injd. intraven. in a dose of 0.8 mg./kg. in dogs with gastric pouches. Pretreatment with benadryl (10 mg./kg. intraven.) usually prevents or reduces these effects. Since ben-adryl does not inhibit histamine-stimulated gastric secretion, the mode of action of benadryl in counteracting Tween 20 stimulated secretion must involve another mechanism.

Keywords

BENADRYL/EFFECTS
STOMACH/SECRETION

This publication has 1 reference indexed in Scilit:

HYPERSENSITIVENESS TO COLD
JAMA, 1936