TREATMENT OF DIABETES INSIPIDUS IN CHILDREN WITH DDAVP, A SYNTHETIC ANALOGUE OF VASOPRESSIN
- 1 March 1973
- journal article
- Published by Wiley in Acta Paediatrica
- Vol. 62 (2) , 133-140
- https://doi.org/10.1111/j.1651-2227.1973.tb08080.x
Abstract
Summary: The effects of a new, synthetic analogue of vasopressin, DDAVP (l‐deamino‐8‐d‐arginine vasopressin), was investigated in 10 children with diabetes insipidus due to deficient secretion of antidiuretic hormone. The lack of pressor activity, and the specific and long‐lasting antidiuretic effect of this preparation was confirmed. During an observation period of 8–19 months it was found that intranasal administration of 1.25‐10 μg of DDAVP twice daily was sufficient to normalize drinking and urine production in all the patients. No side effects were observed. It is concluded that DDAVP is a valuable alternative in the treatment of vasopressin sensitive diabetes insipidus in children, and that it is well suited for long‐term use.Keywords
This publication has 13 references indexed in Scilit:
- EFFECTS OF DDAVP, A SYNTHETIC ANALOGUE OF VASOPRESSIN, IN PATIENTS WITH CRANIAL DIABETES INSIPIDUSActa Medica Scandinavica, 1972
- Long-Term Therapy of Diabetes Insipidus with Oral Benzothiadiazine and Phthalimidine DiureticsClinical Science, 1971
- GROWTH HORMONE RESPONSE TO INSULIN INDUCED HYPOGLYCEMIA IN A BOY WITH DIABETES INSIPIDUS AND SHORT STATURE BEFORE AND AFTER TREATMENT WITH VASOPRESSINActa Paediatrica, 1970
- CHLORPROPAMIDE TREATMENT OF DIABETES INSIPIDUS IN CHILDRENPediatrics, 1970
- Antidiuretic Effect and Complications of Chlorpropamide Therapy in Diabetes InsipidusJournal of Clinical Endocrinology & Metabolism, 1970
- Chlorpropamide-induced hypoglycemia in a child with diabetes insipidusPublished by American Medical Association (AMA) ,1969
- Lypressin nasal spray. Usefulness in patients who manifest allergies to other antidiuretic hormone preparationsPublished by American Medical Association (AMA) ,1968
- PRELIMINARY COMMUNICATIONJournal of Clinical Endocrinology & Metabolism, 1966
- Amino acids and peptides. LX. Synthesis of D-Dab8-vasopressinCollection of Czechoslovak Chemical Communications, 1966
- Synthèse de la désamino1‐Arg8‐vasopressine et de la désamino1‐Phe2‐Arg8‐vasopressine, deux analogues possédant une activité antidiurétique plus élevée et plus sélective que celle des vasopressines naturellesHelvetica Chimica Acta, 1966