The effect of rhodopsin phosphorylation on the light‐dependent activation of phosphodiesterase from bovine rod outer segments

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Abstract
ATP quenches light‐dependent phosphodiesterase (PDE) activation in rod outer segments presumably due to rhodopsin phosphorylation. Here we compared the efficiency of phosphorylated and non‐phosphorylated rhodopsins as PDE activators in a reconstituted cell‐free system. It is shown that the ability of phosphorylated membranes to activate this enzyme is supressed compared with non‐phosphorylated ones.