Estimation of SLE Activity Based on the Serum Level of Chosen Cytokines and Superoxide Radical Generation
Open Access
- 1 January 1999
- journal article
- research article
- Published by Wiley in Mediators of Inflammation
- Vol. 8 (2) , 93-100
- https://doi.org/10.1080/09629359990586
Abstract
We estimated the serum levels of IL‐6, TNF‐α and IL10, and generation of superoxide radicals, as well as their mutual dependence, in 63 SLE patients at various stages of disease activity. Our results indicate a statistically significant increase of the serum levels studied, and an increase of superoxide anion generation by granulocytes, in correlation with SLE activity. These results indicate that oxygen metabolism and the examined cytokines play an important role in pathogenesis of SLE. The assessment of these parameters can be useful in the estimation of disease activity.Keywords
This publication has 27 references indexed in Scilit:
- Serum interleukin 10 titers in systemic lupus erythematosus reflect disease activityLupus, 1995
- Profiles of Cytokines (TNFα and IL-6) and Acute Phase Proteins (CRP and α1AG) related to the Disease Course in Patients with Systemic Lupus ErythematosusLupus, 1993
- Reactive oxygen species modified DNA fragments of varying size are the preferred antigen for human anti-DNA autoantibodiesImmunology Letters, 1992
- Cytokine abnormalities in human lupusClinical Immunology and Immunopathology, 1992
- Impaired tumour necrosis factor-α (TNF-α) production and abnormal B cell response to TNF-α in patients with systemic lupus erythematosus (SLE)Clinical and Experimental Immunology, 1991
- Scavengers of free radical oxygen affect the generation of low molecular weight DNA in stimulated lymphocytes from patients with systemic lupus erythematosusMetabolism, 1990
- CYTOKINES: COORDINATORS OF IMMUNE AND INFLAMMATORY RESPONSESAnnual Review of Biochemistry, 1990
- Reactive oxygen species and airway inflammationFree Radical Biology & Medicine, 1990
- Tumor necrosis factor in the serum of patients with systemic lupus erythematosusArthritis & Rheumatism, 1989
- Production of Tumor Necrosis Factor/Cachectin by Peripheral Blood Mononuclear Cells in Patients with Systemic Lupus erythematosusInternational Archives of Allergy and Immunology, 1989