Management of juvenile laryngeal papilloma: Further observations

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Abstract
Twenty‐two patients with juvenile laryngeal papillomatosis were treated over a five‐year period at The University of Tennessee, using a combination of microsurgical removal and administration of autogenous papilloma vaccine. Twelve patients were classified as having a favorable result. Six were improved, and three were unimproved; one patient was lost to follow‐up. Nine patients have been free of disease for greater than one year. Histologic differences in papillomata removed from patients before and after treatment with the vaccine are reported as are the results of studies attempting to show immunologic response by the gel diffusion and lymphocytic transformation techniques. No conclusions are made as a result of the histologic and immunologic studies. There were no treatment controls other than the response of the individual patient; therefore, no definite conclusions are made concerning this mode of therapy. It is suggested that the results of this clinical study are such that they would tend to indicate that this is a most useful treatment regime.