Drugs Five Years Later
- 1 November 1976
- journal article
- research article
- Published by American College of Physicians in Annals of Internal Medicine
- Vol. 85 (5) , 619-621
- https://doi.org/10.7326/0003-4819-85-5-619
Abstract
Propoxyphene napsylate differs from the hydrochloride salt in several ways. It is much less soluble and bitter and poses few stability problems when capsulated or tableted with aspirin. There is some evidence in several animal species that the pattern and severity of poisoning may be different with the 2 salts. Equimolar doses of the 2 salts are probably interchangeable in the relief of pain. The role of propoxyphene in clinical [human] medicine and the questions of propoxyphene abuse and propoxyphene-related fatalities are discussed.Keywords
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