Effect of Verapamil on the Transmural Energy Metabolism in the Isoproterenol-induced Myocardial Lesion
- 1 January 1978
- journal article
- research article
- Published by International Heart Journal (Japanese Heart Journal) in Japanese Heart Journal
- Vol. 19 (6) , 913-917
- https://doi.org/10.1536/ihj.19.913
Abstract
The effect of verapamil on the isoproterenol (ISO)-induced transmural metabolic lesion in the rat left ventricular wall was investigated. Treatment with ISO 2.5 mg/kg s.c. for 2 days resulted in significant decreases of creatine phosphate in the subendocardium(ENDO) and of ATP in the ENDO and subepicardium. Pi and lactate (LA) were increased in both layers. These changes were more prominent in the ENDO. Pretreatment with verapamil 25 mg/kg s.c. prevented the reduction of high energy phosphate compounds and the increases of Pi and LA in both layers by ISO.This publication has 4 references indexed in Scilit:
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- Nonuniform distribution of blood flow and gradients of oxygen tension within the heartAmerican Journal of Physiology-Legacy Content, 1964
- AN INFARCT-LIKE MYOCARDIAL LESION AND OTHER TOXIC MANIFESTATIONS PRODUCED BY ISOPROTERENOL IN THE RAT1959
- THE DETERMINATION OF INORGANIC PHOSPHATE AND CREATINE PHOSPHATE IN TISSUE EXTRACTSJournal of Biological Chemistry, 1956