THE EFFECTS OF INTRAVENOUS PRISCOLINE ON CEREBRAL CIRCULATION AND METABOLISM 1

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Abstract
Intraven. priscoline in doses from 50 to 100 mg. produces an apparent, though not statistically significant, decrease in cerebral blood flow; an increase in cerebral-arterial venous O2 difference and cerebral-arterial venous glucose difference; a slight decrease in mean arterial pressure; a decrease in arterial CO2 content and arterial CO2 tension; a rise in arterial pH with no alteration in cerebral O2 or glucose consumption, cerebral vascular resistance, arterial O2 saturation or tension; and cerebral venous O2 tension. It is postulated that priscoline produces mild cerebral vasoconstriction and slight hypoxia of brain tissue, though its effects are variable.

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