Problems of Acquired Radioresistance of Cancer: Adaptation of Tumor Cells

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Abstract
The article summarizes the various theories so far advanced for the explanation of acquired radioresistance of malignant tumors. The histologic and radiobiologic behavior of the mucous membrane of the larynx as observed by the author (see preceding abstract) forms the basis for his explanation of this phenomenon. The author explains acquired radioresistance as due to adaptation of cancer cells to the environment, changed by irradiation. Tumor cells which are able to adapt themselves to this changed environment maintain their newly acquired properties in successive cell generations. Thus, gradually the author believes the entire tumor becomes transformed into a growth, the radiobiologic properties of which are adapted to the biologic conditions prevailing during and after irradiation. In these new surroundings, the tumor either disintegrates or its radioresistance is increased.

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