Radioreceptor Assay of Adrenocorticotropic Hormone: New Approach to Assay of Polypeptide Hormones in Plasma
- 6 November 1970
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 170 (3958) , 633-635
- https://doi.org/10.1126/science.170.3958.633
Abstract
Biologically active iodine-125-labeled adrenocorticotropic hormone (ACTH) binds specifically to ACTH receptors extracted from adrenals. Unlabeled ACTH at 1 picogram per milliliter significantly displaces labeled ACTH from these receptors. This system, which appears to be applicable to all polypeptide hormones, provides a rapid and sensitive method for measurements of biologically active ACTH in dilute whole plasma.Keywords
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