Humanization of a murine monoclonal antibody by simultaneous optimization of framework and CDR residues 1 1Edited by J. A. Wells
- 1 November 1999
- journal article
- Published by Elsevier in Journal of Molecular Biology
- Vol. 294 (1) , 151-162
- https://doi.org/10.1006/jmbi.1999.3141
Abstract
No abstract availableKeywords
This publication has 44 references indexed in Scilit:
- Antibody Humanization Using Monovalent Phage DisplayPublished by Elsevier ,1997
- A Combinatorial Library Strategy for the Rapid Humanization of Anticarcinoma BR96 FabJournal of Biological Chemistry, 1996
- Profiles for the analysis of immunoglobulin sequences: Comparison of V gene subgroupsProtein Science, 1995
- Energetics of protein-protein interactions: Analysis ofthe Barnase-Barstar interface by single mutations and double mutant cyclesJournal of Molecular Biology, 1995
- Human-engineered monoclonal antibodies retain full specific binding activity by preserving non-CDR complementarity-modulating residuesProtein Engineering, Design and Selection, 1994
- Antibody framework residues affecting the conformation of the hypervariable loopsJournal of Molecular Biology, 1992
- A possible procedure for reducing the immunogenicity of antibody variable domains while preserving their ligand-binding propertiesMolecular Immunology, 1991
- Phage antibodies: filamentous phage displaying antibody variable domainsNature, 1990
- Canonical structures for the hypervariable regions of immunoglobulinsJournal of Molecular Biology, 1987
- Replacing the complementarity-determining regions in a human antibody with those from a mouseNature, 1986