Coffee and Health: What's Brewing?

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Abstract
IN this issue, Becker et al.1 employ such classic pharmacologic concepts as dose–response relationships and pharmacokinetics, and use established laboratory techniques to show that the well-known actions of caffeine explain the 19th-century observation that asthma was relieved by drinking "strong coffee."2 Salter's century-old description of the response of his patients to coffee2 reminds us of Withering's earlier prescient observations on the response of his patients to "infusions" or "decoctions" of another plant, the foxglove.3 Both descriptions contribute to traditions that have become the basis of modern clinical pharmacology. Of course, purified and standardized cardiac glycosides have replaced infusions of foxglove, . . .

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