Survival after Postoperative Combination Treatment of Rectal Cancer

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Abstract
To the Editor: In 1985, our group reported in the Journal the initial findings of a prospectively randomized clinical trial of 202 patients who had undergone the complete surgical resection of a rectal carcinoma (June 6, 1985, issue).1 We wish to update that report to document the observed survival benefit of combination therapy. In the study, patients whose tumors had penetrated through the bowel wall or spread to regional lymph nodes or both were randomly assigned to receive one of the following: no postoperative treatment, radiation therapy, chemotherapy with semustine (methyl-CCNU) and fluorouracil, or a combination of radiation and chemotherapy. . . .

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