Versatile Defensins
- 1 November 2002
- journal article
- editorial
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 298 (5595) , 977-979
- https://doi.org/10.1126/science.1078708
Abstract
Defensins are antimicrobial peptides produced by immune cells in response to bacterial infection. In his Perspective, Ganz now reveals several new activities for these peptides including the blocking of human host cell invasion by HIV (Zhang et al.) and the induction of cell-mediated immune responses against tumors in mice (Biragyn et al.).Keywords
This publication has 13 references indexed in Scilit:
- Contribution of Human α-Defensin 1, 2, and 3 to the Anti-HIV-1 Activity of CD8 Antiviral FactorScience, 2002
- Toll-Like Receptor 4-Dependent Activation of Dendritic Cells by β-Defensin 2Science, 2002
- A Role for Lipid Shells in Targeting Proteins to Caveolae, Rafts, and Other Lipid DomainsScience, 2002
- Relationship of CD8+ T cell noncytotoxic anti-HIV response to CD4+ T cell number in untreated asymptomatic HIV-infected individualsBlood, 2002
- Discovery of five conserved β-defensin gene clusters using a computational search strategyProceedings of the National Academy of Sciences, 2002
- Defensins of vertebrate animalsCurrent Opinion in Immunology, 2002
- NMR Solution Structure of Murine CCL20/MIP-3α, a Chemokine That Specifically Chemoattracts Immature Dendritic Cells and Lymphocytes through Its Highly Specific Interaction with the β-Chemokine Receptor CCR6Journal of Biological Chemistry, 2001
- β-Defensins: Linking Innate and Adaptive Immunity Through Dendritic and T Cell CCR6Science, 1999
- Crystal Structure of Defensin HNP-3, an Amphiphilic Dimer: Mechanisms of Membrane PermeabilizationScience, 1991
- CD8 + Lymphocytes Can Control HIV Infection in Vitro by Suppressing Virus ReplicationScience, 1986