Effect of Pentoxifylline and its Analogues on Cytokine Activation of Endothelial Cells

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Abstract
The capacity of pentoxifylline and some of its analogues to inhibit endothelial cell activation by tumor necrosis factor (TNF) was investigated. The drugs were added to endothelial cells during incubation with the cytokine. Thromboplastin activity, polymorphonuclear cell and two different carcinoma cell line adhesion were measured. As expected, these parameters were strongly affected by TNF, but the drugs tested did not change TNF activation of the endothelium. The drugs were also inactive on endotoxin induced interleukin-6 production by endothelial cells. These data suggest that the beneficial effect of pentoxifylline observed in a series of experimental models of inflammation is not due to a change in the endothelial cell prothrombotic and proinflammatory properties.

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