ANTAGONISM TO THE ACTIONS OF HYDRALLAZINE, RESERPINE, POTASSIUM CYANIDE, SODIUM AZIDE AND ANOXIA ON ARTERIAL SMOOTH MUSCLE

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Abstract
Many intermediates of carbohydrate, fat and protein metabolism give protection against the hydrallazine depression of acetylcholine, (-)-adrenaline, (-)-noradrenaline, histamine and 5-hydroxytryptamine-induced contractions of spirally cut strips of horse carotid arteries. Strips made anoxic behave in a manner similar to hydrallazine-treated strips. Inhibition of drug-induced contractions by potassium cyanide, iodoacetate and azide was of a different character from that caused by hydrallazine and anoxia. Few intermediates gave significant protection. Hydrallazine probably exerts its effect by a non-specific depression of metabolism rather than upon specific receptors. Reserpine depression of drug-induced contractions in artery strips was so persistent that experiments using intermediary metabolites could not be made.