Action of Deoxycorticosterone Acetate on the Central Artery of the Rabbit Ear

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Abstract
An inhibitor of extraneuronal uptake, deoxycorticosterone acetate (DOCA), increased the sensitivities of the rabbit ear artery to extraluminal and to intraluminal epinephrine, each approximately 3-fold. The effect on extraluminal epinephrine was increased in cocaine-treated or chronic sympathetic denervated arteries. Sensitizing actions of DOCA were due to inhibition of extraneuronal uptake was suggested by the relative magnitudes of its sensitizing effects on the 3 amines [in decreasing order, epinephrine > isoprenaline (.beta.-stimulation) > norepinephrine] and by its ability to prevent the potentiation of epinephrine by normetanephrine. The uptake system was readily saturated due to the sensitizing actions of DOCA decreased by procedures which decreased the potencies of epinephrine and isoprenaline, namely, phentolamine, and doses of isoprenaline eliciting constriction via .alpha.-stimulation, respectively.

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