Dependence of Collagen Synthesis by Embryonic Chick Tendon Cells on the Extracellular Concentrations of Glutamine
- 1 January 1978
- journal article
- research article
- Published by Taylor & Francis in Connective Tissue Research
- Vol. 6 (3) , 155-159
- https://doi.org/10.3109/03008207809152625
Abstract
An agent in rheumatoid synovial fluid which stimulates collagen synthesis by embryonic chick tendon cells was identified as glutamine. The stimulating effect was observed only at a subnormal concentration of pro-line (0.02 mM). The concentration of glutamine in rheumatoid synovial fluid is about 2.5 mM but it falls rapidly during storage even at - 20 °C. Collagen synthesis is shown to depend on the extracellular concentrations of glutamine and proline in addition to any connective tissue activating factors.This publication has 20 references indexed in Scilit:
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