Changes in Blood Viscosity, Hematocrit Value, and Fibrinogen Concentration in Subjects with Congestive Heart Failure

Publisher Website
Google Scholar
Abstract
This study was undertaken to assess the role of changes in blood viscosity in the tendency toward thrombosis in persons with congestive heart failure. Measurements of blood viscosity (cone-plate), hematocrit, and fibrinogen concentration were made at the height of the congestive process and repeatedly thereafter as compensation was restored in 30 patients. Viscosity was normal or only slightly increased prior to treatment. However, with diuresis and restoration of compensation there was a 41.7% increased in blood viscosity. This increase correlated closely with a commensurate increase in hematocrit and fibrinogen concentration; blood volume studies in 5 subjects revealed that all of these changes were likely the consequence of a selective contraction of the plasma volume. The maximum increase occurred between the 3rd and 10th days, which is the danger period for thrombo-occlusive events.