Antibodies to HIV in Saliva

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Abstract
To the Editor: Conventional enzyme-linked immunosorbent assays (ELISAs) have been reported1 to have low rates of detection (50 to 57 percent) for antibody to the human immunodeficiency virus (HIV) in saliva2 from seropositive patients. We chose to reinvestigate the suitability of a second-generation, recombinant protein-based ELISA to detect antibodies to HIV in matched scrum and saliva samples from 14 patients with the acquired immunodeficiency syndrome (AIDS). Saliva from five seronegative laboratory workers was used for negative controls. The substitution of saliva (at a 1:10 dilution) for serum resulted in the detection of antibodies to HIV in 86 percent of seropositive . . .