The metabolism of oxamniquine—a new schistosomicide
- 31 August 1976
- journal article
- research article
- Published by Taylor & Francis in Pathogens and Global Health
- Vol. 70 (3) , 323-328
- https://doi.org/10.1080/00034983.1976.11687128
Abstract
The metabolism of oxamniquine, 6-hydroxymethyl-7-nitro-2-isopropylaminomethyl-1,2,3,4-tetrahydroquinoline, was studied in the mouse, rat, hamster, rabbit, rhesus monkey, dog and man. Urinary excretion is a major route of elimination in man. The compound is converted to 2 metabolites, the major one arising from oxidation of the 6-hydroxymethyl group to a carboxyl group and the other by oxidation of the side chain to give the 2-carboxylic acid. There is a species difference at the dose levels used since both acidic metabolites were found in appreciable quantities only in the urine of mouse, rabbit, hamster and dog. The 2-carboxylic acid was not found in the urine of rhesus monkey and rat and occurred in only trace amounts in human urine.This publication has 6 references indexed in Scilit:
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