Effects of cyproterone acetate and carboxylic acid derivatives on the sebaceous glands of the Syrian hamster

Publisher Website
Google Scholar
Abstract
Summary The Syrian hamster ear model was used to study effects of the anti-androgen cyproterone acetate and of the anti-lipogenic compound 17β-carboxylic acid methyl ester and its ethyl ester. The steroid derivatives were applied topically in a 1–2% concentration or given systemically. Response of sebaceous gland was measured by means of cell proliferation (3H-TdR autoradiography) and by gland size (histoplanimetry). Cyproterone acetate significantly reduced the labelling and the planimetric value, both topically and systemically. The carboxylic acid derivatives, which block the 5α-reductase were ineffective. The new animal model is a sensitive and suitable means to study inhibition of sebum production.

This publication has 30 references indexed in Scilit: