Urinary excretion of pyridinoline and deoxypyridinoline: Circadian rhythm in healthy premenopausal women

Publisher Website
Google Scholar
Abstract
Urinary cross‐linking amino acids (pyridinoline and deoxypyridinoline) are used as biochemical markers of bone resorption. Therefore, the study of their diurnal behavior might provide information on whether circadian variability could be observed in bone remodelling. We showed a significant circadian rhythm of both urinary pyridinoline and deoxypyridinoline in healthy premenopausal females with higher concentrations at 05.35 and 0457, respectively. The reported observations suggest an increased rate of bone resorption during the night in subjects living on a usual day‐night schedule. Moreover, these findings focus the attention on the importance of the sampling time for the comparison of data from different studies and from patients with different pathological conditions.

This publication has 14 references indexed in Scilit: