Synthetic applications of N–N linked heterocycles. Part 11. Regiospecific synthesis of dialkyl pyridin-4-yl-, quinolin-4-yl-, and isoquinolin-1-yl-phosphonates
- 1 January 1981
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- p. 668-671
- https://doi.org/10.1039/p19810000668
Abstract
Treatment of N-(2,6-dimethyl-4-oxopyridin-1-yl)-pyridinium, -quinolinium, and -isoquinolinium salts with trialkyl phosphites in the presence of sodium iodide gives regiospecifically dihydro-intermediates, which may be decomposed in good yields to dialkyl pyridin-4-yl-, quinolin-4-yl-, and isoquinolin-1-yl-phosphonates respectively. The reaction may also be carried out in one step without isolating the dihydro-intermediate.Keywords
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