Immunity Following Oral Administration of Poliomyelitis Virus to Monkeys

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Abstract
Summary: A study has been carried out on the development of antibodies and of immunity in cynomolgus monkeys following the ingestion of poliomyelitis virus (Y-SK strain). Thirty-one per cent of the animals developed paralysis after the feeding, and these animals were found to have developed antibodies by the first day of disease. In contrast no antibodies were detected on the first day of paralysis in 20 monkeys receiving virus by the intranasal route. Further investigation was made of the immune status of animals which failed to develop disease following virus ingestion: 63 % (29 of 46) developed antibodies and of those challenged by the intranasal or intracerebral routes 18% (4 of 22 were susceptible). 37% (17 of 46) failed to produce antibodies and of those challenged, 73% (8 of 11) proved susceptible. 96% (30 of 32) of the control groups developed paralytic poliomyelitis. There was a correlation between the level of antibodies in serum and the resistance to the challenge dose of virus.