LETHAL EFFECTS OF LOW AND "NULL" ACTIVITY ALLELES OF 6-PHOSPHOGLUCONATE DEHYDROGENASE IN DROSOPHILA MELANOGASTER
Open Access
- 1 March 1975
- journal article
- research article
- Published by Oxford University Press (OUP) in Genetics
- Vol. 79 (3) , 451-457
- https://doi.org/10.1093/genetics/79.3.451
Abstract
EMS-induced "null" and low activity alleles for 6-phosphogluconate dehydrogenase were characterized with respect to enzymatic activity, relative viability, fertility, and the effective lethal phase. It was determined that flies hemizygous and homozygous for the low activity allele, Pgd -, possessed a depressed developmental rate, diminished viability, and loss of female fertility. Heterozygotes for Pgd - and a deficiency for Pgd + were lethal. The "null" activity allele demonstrated a lethal phenotype in both the hemizygous and homozygous condition. The effective lethal phase for the "null" allele occurs during late embryonic development (20-22 hr).Keywords
This publication has 7 references indexed in Scilit:
- The recovery, penetrance, and pleiotropy of X-linked, cold sensitive mutants in DrosophilaMolecular Genetics and Genomics, 1973
- On Estimating Functional Gene Number in EukaryotesNature New Biology, 1973
- The -glycerophosphate in Drosophila melanogaster. II. Genetic aspects.1972
- DOSAGE COMPENSATION FOR ENZYME ACTIVITIES IN Drosophila melanogasterProceedings of the National Academy of Sciences, 1969
- Molecular Size Studies on 6-Phosphogluconate DehydrogenaseNature, 1966
- X-Linked 6-Phosphogluconate Dehydrogenase in Drosophila : Subunit AssociationsScience, 1965
- PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENTJournal of Biological Chemistry, 1951