Decoding calcium signals involved in cardiac growth and function
- 1 November 2000
- journal article
- review article
- Published by Springer Nature in Nature Medicine
- Vol. 6 (11) , 1221-1227
- https://doi.org/10.1038/81321
Abstract
Calcium is central in the regulation of cardiac contractility, growth and gene expression. Variations in the amplitude, frequency and compartmentalization of calcium signals are decoded by calcium/calmodulin-dependent enzymes, ion channels and transcription factors. Understanding the circuitry for calcium signaling creates opportunities for pharmacological modification of cardiac function.Keywords
This publication has 78 references indexed in Scilit:
- PKA Phosphorylation Dissociates FKBP12.6 from the Calcium Release Channel (Ryanodine Receptor): Defective Regulation in Failing HeartsPublished by Elsevier ,2000
- β-ADRENERGIC RECEPTORS AND RECEPTOR SIGNALING IN HEART FAILUREAnnual Review of Pharmacology and Toxicology, 1999
- Altered cardiac excitation–contraction coupling in mutant mice with familial hypertrophic cardiomyopathyJournal of Clinical Investigation, 1999
- Relationship Between Na + -Ca 2+ –Exchanger Protein Levels and Diastolic Function of Failing Human MyocardiumCirculation, 1999
- “Stress-Responsive” Mitogen-Activated Protein Kinases (c-Jun N-Terminal Kinases and p38 Mitogen-Activated Protein Kinases) in the MyocardiumCirculation Research, 1998
- A Mutant Tropomyosin That Causes Hypertrophic Cardiomyopathy Is Expressed In Vivo and Associated With an Increased Calcium SensitivityCirculation Research, 1998
- Phospholamban: A Prominent Regulator of Myocardial ContractilityCirculation Research, 1996
- Excitation-contraction coupling in heart: new insights from Ca2+ sparksCell Calcium, 1996
- Altered sarcoplasmic reticulum Ca2(+)-ATPase gene expression in the human ventricle during end-stage heart failure.Journal of Clinical Investigation, 1990
- Abnormal intracellular calcium handling in myocardium from patients with end-stage heart failure.Circulation Research, 1987