Delayed neurotoxicity of cyanofenphos in chickens

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Abstract
Delayed neurotoxic ataxia, similar to that caused by neurotoxic organophosphorous compounds, occurred in hens after oral administration of cyanofenphos (O-ethyl-O-cyanophenyl phenyl phosphonothionate) [an insecticide] following either single or repeated oral doses. Axonal and myelin degeneration affecting the long tracts in spinal cord, peripheral nerves and medulla was demonstrated. The distal fibers with large diameters were particularly affected. A thorough study of the structure-activity relationships of phosphonothionates regarding their delayed neurotoxic effect is evidently warranted.