STUDIES ON ANTIDIABETIC AGENTS - SYNTHESIS AND HYPOGLYCEMIC ACTIVITY OF 5-[4-(PYRIDYLALKOXY)BENZYL]-2,4-THIAZOLIDINEDIONES

  • 1 January 1990
    • journal article
    • research article
    • Vol. 40-1  (1) , 37-42
Abstract
The synthesis of a series of 5-[4-(pyridylalkoxy)benzyl]-2,4-thiazolidinediones is described. These compounds were evaluated for hypoglycemic and hypolipidemic activities in genetically obese and diabetic mice, yellow KK. 2-(2-Pyridyl)alkoxy derivatives were found to have much better hypoglycemic and hypolipidemic activities than 2-(3-pyridyl)- and 2-(4-pyridyl)alkoxy derivatives or even the previously reported compound, ciglitazone. The introduction of a hydroxyl group at the 2-position of the ethoxy chain potentiated the activities. Among the potent compounds, pioglitazone (AD-4833) was selected as a candidate compound.