Anaphylactic Reaction to Chymotrypsin

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Abstract
MANY TECHNIQUES have been suggested for the relief of the painful episiotomy wound. Enzymatic treatment is one of the newer methods. Chymotrypsin, one of the drugs used for this purpose, is a proteolytic enzyme extracted from the mammalian pancreas. As with any foreign protein there is danger of a hypersensitivity response after its administration, and, in fact, the anaphylactic reaction to chymotrypsin in guinea pigs was once suggested as a means of differentiating chymotrypsin from trypsin. It has been further demonstrated that bovine chymotrypsin can produce strong allergic sensitization with transferable skin-sensitizing antibodies against the enzyme. There have been at least 2 reports in the literature of well documented accidental hypersensitivity in laboratory personnel dealing with trypsin and chymotrypsin. There are at least 3 anaphylactic responses to chymotrypsin reported among patients receiving it in an attempt to provide an enzymatic debridement. This is the first case report in obstetrics. Prior

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