Intracellular Crystal Formation as a Mechanism of Cytotoxicity in Murine PulmonaryCryptococcus neoformansInfection
Open Access
- 1 April 2001
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 69 (4) , 2723-2727
- https://doi.org/10.1128/iai.69.4.2723-2727.2001
Abstract
Rod-like crystalline structures formed during eosinophilicCryptococcus neoformanspneumonia in C57BL/6 mice. Crystals were found associated with yeast cells and free in host cell cytoplasm. The crystals apparently formed because of the interaction of a host protein with the cryptococcal polysaccharide. Crystal formation likely contributes to pathogenesis by causing cellular damage.Keywords
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