Mutational analysis of enhancer domains responsive to trans-activation by the X gene of human hepatitis B virus

1 September 1990

journal article
research article
Published by Springer Nature in Archiv für die gesamte Virusforschung

Vol. 114 (3-4) , 237-242
https://doi.org/10.1007/bf01310752

Abstract

The X gene product of human hepatitis B virus (HBV) trans-activates the HBV enhancer. In order to identify domains responsive to trans-activation by the X gene, we introduced a series of mutations into the HBV enhancer and assayed the enhancer activities in the presence of the X gene product. Our results suggest that the EP domain of the enhancer is essential for trans-activation by the X gene.

Keywords

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