The diuretic effect of desmethyl‐pipazuroyl‐guanidine (MK‐870) in man

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Abstract
The diuretic properties of desmethyl‐pipazuroyl‐guanidine (MK) have been investigated in man and compared with hydrochlorothiazide (HC). In single‐dose studies MK (30 mg.) had a slower onset of action and lower peak response than H C. It caused K + retention and did not affect Cl output. When administered daily for five days, MK again had a lower peak response than HC, but its effect was maintained for a longer period and after five days the natriuresis produced by each drug was approximately the same. When MK and HC were given together, there was a greater natriuresis and the K loss produced by HC was reduced. Both diuretics lowered blood pressure, but MK appeared to be less effective than HC.

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